Avoid These Dangerous Suboxone Drug Interactions

There are over 150 known severe drug interactions between Suboxone and other medications. This number does not include moderate interactions. There are four ways to avoid a dangerous drug interaction. These ways are:

  • Stop taking the medication
  • Switch to an alternative medication
  • Suboxone medication dosage reduction
  • Engage in monitoring at a drug treatment center

One of these ways should prevent a dangerous Suboxone drug interaction. Unfortunately, the medications that Suboxone interacts poorly with are sometimes vital for your health and welfare. This is where a qualified treatment center can help. To avoid all of these interactions, call 888-646-0865 (Who Answers?) . We can help.

Chronic Infections

Many times, opiate use disorder spawns chronic infections because it weakens your immune system. If you have chronic infections, you have to be very careful to avoid certain antibiotics.

Depression and Anxiety Medication

Most antidepressants (particularly tricyclic antidepressants) interact with Suboxone, which causes a worsening of depression or suicidal ideation.

Both medications for anxiety and antidepressants are central nervous system depressants. According to prescribing information, these CNS depressants may cause coma and death when combined with Suboxone.

Menopause Medications

Suboxone causes endocrine dysfunction. When you mix it with an estrogen replacement medication, it becomes more imbalanced. Estrogens and other drugs for menopause are not recommended during Suboxone treatment.

Allergy, Cold, and Flu Medications

Many allergy, cold, and flu medications contain acetaminophen or alcohol. Mixing any alcohol with Suboxone is extremely dangerous. Mixing acetaminophen with Suboxone may cause liver damage. It is best that you do not take allergy, cold, or flu medications when you are on Suboxone, unless your usage is strictly supervised.

Some Vitamins and Nutritional Supplements

According to the National Library of Medicine, some vitamins and nutritional supplements will interact negatively with Suboxone. It is best to speak with your doctor or treatment center before taking these.

HIV/ Aids Medications

Retro antivirals, HIV protease inhibitors, and antibiotics all have a very serious interaction with Suboxone. In some cases, Suboxone use may be reduced and the patient monitored very closely for an adverse reaction. The combination may cause reduced effectiveness in:

  • Antivirals
  • Inhibitors
  • Antibiotics
  • Suboxone

The close monitoring required is best done while in the care of a treatment center.

What Are the Most Difficult to Deal with Suboxone Side Effects?

Seizure Disorder or Epilepsy

Medications that prevent seizures or treat epilepsy are highly reactive with Suboxone. They can cause convulsions and overdose depending on the type of medication. If you have epilepsy or another seizure disorder, you should consider inpatient or closely monitored outpatient treatment.

Avoiding the Dangerous Drug Interactions

This is not a complete list of all of the medications with which Suboxone reacts. Many others may cause issues such as:

  • Coma
  • Seizures
  • Overdose
  • Respiratory failure
  • Heart failure
  • Liver failure
  • Death

You can only avoid these complications by:

Suboxone drug interactions are dangerous and difficult to keep up with on your own. It is important to find a qualified treatment center or doctor. To find one, all you have to do is call 888-646-0865 (Who Answers?) . We can help you locate the treatment you need to avoid these interactions.


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By calling the helpline you agree to the terms of use. We do not receive any commission or fee that is dependent upon which treatment provider a caller chooses. There is no obligation to enter treatment.

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